Arriving from the North (Milan, Florence): - The best exit for Perugia on the Florence-Rome A1 motorway is the Valdichiana exit. - From there take the SS75bis motorway, entering Umbria at Lake Trasimeno and continuing until you reach Perugia. - To reach the Hotel Perusia e la Villa turn off the motorway at the Perugia-Piscille exit. - Follow signs for the centro (center) and then for the ospedale di Monteluce (Monteluce hospital). Arriving from the South (Rome): Driving on the Florence-Rome A1 motorway (Autostrada del Sole) coming from the South, the best exit for reaching Perugia is Orte. - From the Orte exit, first follow SS204 (toward Terni), then take the E45 (or SS3bis) from Terni to Perugia. - When arriving in Perugia, to reach the Hotel Perusia e la Villa take the Perugia-Piscille exit. - Follow signs for the centro (center) and then for the ospedale di Monteluce (Monteluce hospital).